30 July 2008 – Silence Therapeutics plc (AIM: SLN), a leading European RNAi focused biotechnology company, announces that its partner, Quark Pharmaceuticals Inc (“Quark”) together with Pfizer, has commenced a Phase II clinical trial with RTP-801i-14 (PF-4523655), a small interfering RNA (siRNA) therapeutic product based on Silence’s AtuRNAi technology. Its initiation triggers a $1.9 million milestone payment to Silence from Quark.
The study is designed to evaluate the effectiveness of the candidate in improving visual acuity compared to laser treatment in patients with diabetic macular oedema. The Phase II study is being funded and is conducted by Pfizer Inc in collaboration with Quark.
Pfizer in-licensed RTP-801i-14 from Quark in a deal announced in 2006 for the treatment of age-related macular degeneration (AMD) and other ophthalmologic and non-ophthalmologic indications... Silence Therapeutics' Press Release - Quark Pharmaceuticals' Press Release -
